Modeling the Budding Yeast Cell Cycle

GAL-CLB2 cdh1∆

debug: ,
test user =
test db =

Simulation:

Change of parameters: ksb2'=0.12, kscdh=0, MDT=150, init CDH1=CDH1T=0.
Arrest: Telophase arrest and unbudded.

Experiments:

Cross, F.R. (2003). Two redundant oscillatory mechanisms in the yeast cell cycle. Dev. Cell 4:741-752.
[Abstract] [Article]
Experimental results: Inviable (data not shown). It arrests with a mixture of large budded and unbudded cells, more unbudded cells than with GAL-CLB2-db∆.
Comments: The mutant is considered as unbudded because [Bud]max=0.18 < 1, whereas GAL-CLB2-db∆ is considered budded because [Bud]max=1.5 > 1.